The ultra-low-power Atmel® Cortex® M0+ SAM L21 device achieves very low power consumption while performing tasks in sleep modes. In this application note it is described how to configure a SAM L21 Xplained Pro to sample a sequence of inputs using the ADC while achieving a very low power consumption in Standby sleep mode. The ADC sampling is triggered by RTC periodic events and the results are stored in RAM using DMA. Sampling a sequence of three inputs 32 times per second results in an average power consumption of 1.7μA.