Be aware that if your Windows OS version of WinUSB drivers is older than the IDE preinstaller version, the system drivers will be replaced. If you want to keep your version of WinUSB drivers, rename these files before installing MPLAB X IDE.
The WinUSB driver files are located at the following locations:
32-bit OS
C:\Windows\system32\WinUSB.dll
(32-bit)
C:\Windows\system32\drivers\WinUSB.sys
(64-bit)
64-bit OS
C:\Windows\SysWOW64\WinUSB.dll
(32-bit)
C:\Windows\system32\WinUSB.dll
(64-bit)
C:\Windows\system32\drivers\WinUSB.sys
(64-bit)